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  •   Behzad Moradi
  • Behzad Moradi
     Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

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  •   Saber Abbaszadeh 
  • Saber Abbaszadeh
    home remedies for diabetes 🔥how to home remedies for diabetes for  Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

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  •   Somayeh Shahsavari
  • Somayeh Shahsavari
    home remedies for diabetes 🔥how to home remedies for diabetes for  Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

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  •   Mohsen Alizadeh
  • Mohsen Alizadeh
     Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

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  •   Fatemeh Beyranvand
  • Fatemeh Beyranvand
     Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

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Table of Contents for 1 last update 2020/06/01 Article Article
More author''rhizome ethanol extracts (ZZRext) After three months of diabetes, the weight gain in STZ-diabetic rats was significantly less when compared with normal rats, and the blood glucose levels were significantly higher The reduction in body weight was not obvious in STZ-diabetic rats receiving ZZRext during the experimental period. 23 24 Kaempferia parviflora root Zingiberaceae (KP) or Krachaidum belongs orThai ginsengs in Thailand Thailand In vitro2017 KP ( Kaempferia parviflora )treatment demonstrated a significant recovery of sexual behaviour and serum testosterone levels in diabetic rats. 24

Table 5.

Medicinal herbs and for 1 last update 2020/06/01 therapeutic information in diabetes (Table 1 continued) Medicinal herbs and therapeutic information in diabetes (Table 1 continued)

No. Scientific Name Part of plant Family Name Common Name Origin of plant CountryOf study Year Result Reference
25 Opuntia megacantha leaves Cactaceae culinary South Africa andSouth America Zimbabwe 1999invitro Administration of the leaf extract was also associated with an increased GFR in STZ-diabetic rats. although the rate was unaltered in non-diabetic rats. 25
26 Symplocos coccinea Seed and leaves Symplocaceae endemic to Mexico India Invitro2014 But SCE (hydroethanol Extract of Symplocos cochinchinensis) Administration resulted in a lower plasma level of urea and creatinine in treated groups compared to the diabetic control group This Shows protective property of SCE Against renal damage. 26
27 perilla Leaves Lamiaceae "" America and Asia and Europe Japan In vivo2005 The flavonoid luteolin from perilla luteolin treatment prevented the development of diabetic nephropathy by significantly lowering BUN and creatinine in diabetic animals. This could be explained that there was increased clearance of blood urea and creatinine by the kidney or that there was decreased protein degradation. Moreover, luteolin also prevented the increase in 24-h urea protein in diabetic rats. 27
28 Allium sativum Seed Amaryllidaceae Garlic China and common seasoning worldwide. Iran Invitro2016 Garlic extract has the opposite effect on the renal function markers and histopathology of diabetic rats. Since hyperglycaemia causes the diabetic complications, compounds that have hypoglycaemic effects can be effective in reducing of diabetic complications such as renal dysfunction. 28
29 Terminaliachebula seeds Combretaceae chebulic myrobalan South Asia from India and Nepal east to southwest China Canada Invitro2006 T. chebula is more effectively inhibited the incidence of diabetic nephropathy. Diabetic nephropathy is mainly associated with excess urinary albumin excretion, abnormal renal function as represented by an abnormality in serum creatinine. 29
30 Aloe vera . Burm leaf Asphodelaceae Aloe vera around the world Turkey Invitro2003 the function and structure of kidney may be affected by changes in the levels of insulin Diabetic kidney exhibits characteristic changes leadin to renal insufficiency or complete kidney failure. The major alteration was observed especially in the proximal tubules of the kidney tissue in the diabetic animals. The rupturing of the brush border, shows that the structural integrity of the membrane was disrupted. 30

home remedies for diabetes 👍how to home remedies for diabetes for Table 6.

Antidiabetic mechanism activity of medicinal herbs

Scientific Name Mechanism Ref.
URTICA DIOICA(U. dioica) The aqueous UD extract plays an important role by improving the morphology and / or function of beta cells. Preventing damage to beta-cell cells, repair damaged beta cells, rebuilding new cells, and stimulating insulin secretion in functional cells is one of the mechanisms of action of the extract of this plant 15
Trigonella foenum graecum The therapeutic effect of fenugreek seed on diabetes is at least partly due to the direct stimuli of an amino acid called hydroxysolecuine-4 on insulin secretion from beta cells. Following cell damage, the activity of Ca ATPase and Na / K ATPase pumps decreases the consumption of fenugreek seeds by reducing the free radicals, eliminating these disorders. 16
Carthamus tinctorius The rich source of flavonoids, such as quercetin and camphorol, is linked to its antioxidant and hypoglycemic activity. 16
Ferula assa-foetida Due to the presence of antioxidant compounds, gum can reduce the amount of intracellular free radicals and stimulate the synthesis and secretion of insulin or hyperplasia of the remaining beta cells in the pancreas. Anthoczone gum may reduce blood glucose by stimulating the synthesis and secretion of insulin and hyperplasia of the remaining beta pancreatic beta cells. 17
Bauhinia forficata It is rich in polyphenolic antioxidant compounds, flavonoids, which reduce blood glucose by increasing insulin secretion and inducing glucose transfer through insulin-dependent pathways. 17
Gymnema sylvestre Gymnemic acid molecules have a receptor on the surface of the outer layers of the intestine that prevents the absorption of sugar molecules by the intestine, which leads to a decrease in blood sugar levels. 18
Swertia punicea The mechanism of action of the Swertia Punicea Glucose Reducing Effect by Improving Insulin Resistance, which increases the absorption and secretion of insulin. 18
Combretum Micranthum Stimulates the synthesis and secretion of insulin or hyperplasia of the remaining beta cells in the pancreas. 18
Sarcopoterium spinosum The blue extract of the root of the Sarcopoterium spinosum plant exhibits activity similar to insulin. 18
Liriope spicata Increases insulin secretion and absorption, and improves glucose tolerance in the body. 30
Caesalpinia bonducella Increases insulin secretion from pancreatic islets. The anti-hyperglycaemic effect of the plant''s erythrocytes. 19
Mangifera indica This may be due to decreased intestinal absorption of glucose. 19

Table for 1 last update 2020/06/01 7. Table 7.

Antidiabetic mechanism activity of medicinal herbs (Table 1 continued)

Scientific Name Mechanism Ref.
Momordica charantia It inhibits glucose 6-phosphatase in addition to fructose-1, 6- bis-sepsfatase in the liver and stimulates glucose 6-phosphate dehydrogenase 19
Salvia nemorosa Inhibiting insulin secretion in response to glucose stimulation, the plant inhibits insulin resistance. 20
Ginseng Ginseng has a blood glucose-lowering effect that stimulates insulin secretion, protects pancreatic islets, stimulates glucose uptake, and increases insulin sensitivity. 21
Momordica charantia Bitter melon increases the anti-hyperglycemic effects by inhibiting protein tyrosine phosphatase 1B (PTP1B), activating AMPK, increasing the expression of type 4 glucose (GLUT4), enhancing beta cellularity and insulin effects. 21
Trigonella foenum-graecum Its antihyperglycaemic mechanisms were associated with increased insulin secretion, increased insulin sensitivity, and inhibition of digestion and intestinal carbohydrate intake. 21
Allium sativum These effects are mainly caused by repair of insulin responses and inhibition of glucose intestinal absorption. These effects of the pancreas β result in stimulation of insulin secretion from the cells. 21
Cinnamon Lowering effects work by promoting insulin secretion, increased insulin sensitivity, and increased glucose elimination. Also, cinnamon seemed to have insulin-like effects by regulating PTP1B and insulin receptor kinase. 21
Dendrobiumchrysotoxum DC Increases expression mRNA Retina in an intercellular adhesion molecule (ICAM-1 ) , Tumor necrosis factor α (TNFα) , Interleukin (IL-) 6And IL-1β In diabetic rats . Furthermore, DC Reduction of phosphorylationP65 , IκB And kinase IκB (IKK) In Diabetic Rat A. 22
Zingiber zerumbet Treatment ZZRext Triggers active nuclear activation _B (NF-_B) , As well as expression of the active protein protein kinase protein p38 (MAPK) In the retina of the diabetic . 23
Kaempferia parviflora Extract KP With increasing protein 1 (UCP1) In the fat tissue of coffee in mice and humans, it increases the cost of energy . 24
Opuntia megacanth Reduces plasma concentration Na_ , Simultaneously with the reduction of plasma ions concentration . Leaf extract O. megacantha Significantly increased creatinine and plasma urea concentration A. 25
Symplocos coccinae It increases the activity of aldose reductase and stores glycogen and protein in the muscle. 26
perilla Hyperglycemia effect of Perila leaf growth factor PLE) is derived, at least in terms of reduced glucose uptake, in the small intestine. Improved tolerance to Glucose PLE may be due to direct inhibition of glucose uptake in the small intestine. 27
Allium sativum Garlic stimulates insulin secretion. Effect is by restoration of insulin and inhibition of absorption from intestines and glucose creation. 28
Terminalchebula Due to its significant hypoglycemia, the extract may inhibit the formation of advanced glycosylated products. It is possible to increase the secretion of insulin from beta-lancer cells. 29
Aloe vera. Burm The polyphenols of this plant in the islands β by increasing the stimulation of langerhans cells, more insulin is released, due to the presence of compounds such as flavonoids and glycosides in this plant. 30

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Diabetes is a condition that is characterized by high blood sugar levels. Millions of people worldwide are affected by the disease. Research on diabetes is ongoing. 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