how to raise blood sugar level from 60 to 300 slots for fun 8 Wonder Herbs That Are Considered as Safe Ayurvedic Sugar ... These diabetic herbs are beneficial in promoting healthy metabolic function.
aDepartment of Nutrition and Biochemistry, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
bDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
cIranian Diabetes Association, Tehran, Iran.
dDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
eRazi Hospital-Psychiatry, Tehran, Iran.
fRazi Hospital-Psychiatry, Tehran, Iran.
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Anti-diabetic, hypolipidemic and anti-oxidative properties of ginger have been noticed in several researches. The present study was conducted to investigate the effects of ginger on fasting blood sugar, Hemoglobin A1c, apolipoprotein B, apolipoprotein A-I, and malondialdehyde in type 2 diabetic patients. In a randomized, double-blind, placebo-controlled, clinical trial, a total of 41 type 2 diabetic patients randomly were assigned to ginger or placebo groups (22 in ginger group and 19 in control group), received 2 g/day of ginger powder supplement or lactose as placebo for 12 weeks. The serum concentrations of fasting blood sugar, Hemoglobin A1c, apolipoprotein B, apolipoprotein A-I and malondialdehyde were analyzed before and after the intervention. Ginger supplementation significantly reduced the levels of fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein B/apolipoprotein A-I and malondialdehyde in ginger group in comparison to baseline, as well as control group, while it increased the level of apolipoprotein A-I (p<0.05). It seems that oral administration of ginger powder supplement can improves fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein A-I, apolipoprotein B/apolipoprotein A-I and malondialdehyde in type 2 diabetic patients. So it may have a role in alleviating the risk of some chronic complications of diabetes.
Diabetes mellitus can be defined as a group of metabolic diseases characterized by chronic hyperglycemia resulting from impaired insulin action/secretion and is classified into two major categories, type 1 and type 2. Type 2 diabetes accounts for >90% of diabetes and is resulting in impaired function in carbohydrate, lipid and protein metabolism. Effective control of hyperglycemia in diabetic patients is critical for reducing the risk of micro- and macro-vascular diseases (1).
The prevalence of diabetes mellitus has reached epidemic proportions and has affected 6.4% of adults worldwide in 2010 (2). The global prevalence for all age groups was estimated to be 4.4% in 2030 (3). The number of patients suffering from diabetes, among the 25-64 years old Iranians is 7.7%, equal to 2 million patients, which half of them are not aware of their disease. As well as, 6.8%, equal to 4.4 million of Iranian adults have impaired fasting glucose (4).
Dyslipidemia (lipid abnormalities) resulting from uncontrolled hyperglycemia and insulin resistance in diabetic patients is a major risk factor for coronary artery disease, stroke and peripheral vascular disease (5).
Recently, attention has been focused on the relationship between production of free radicals, especially reactive oxygen species (ROS), and the pathogenesis as well as progression of diabetes mellitus. Mechanisms that contribute to the formation of free radicals in diabetes mellitus may include metabolic stress resulting from changes in energy metabolism, inflammatory mediators and impaired antioxidant defense mechanisms (5). Hyperglycemia increases oxidative stress through the overproduction of reactive oxygen species, which results in an imbalance between free radicals and the antioxidant defense system of the cells (3). It was reported that oxidative stress which affects carbohydrate, lipid and protein metabolism (3), increase in patients with diabetes mellitus and suggested to induce endothelial cell dysfunction and trigger the progression of atherosclerosis (6). The elevated blood glucose levels in diabetes are thought to lead to cell death through oxidative stress induction (3). Because of the increased risk of cardiovascular disease in these patients, the preventive strategy of normal blood lipids and reduction of oxidative stress should be considered.
Apart from conventional anti diabetic therapy, medicinal plants, complementary and alternative medicine therapies have beneficial effects and improve glucose homeostasis in diabetic patients (7). Several ethno pharmacological studies on medicinal plants having beneficial effects on diabetes have been reported (8). Ginger is an underground rhizome of plant Zingiber officinale belonging to the family Zingiberaceae and it is one of the most widely consumed spices worldwide. It has a long history of use as herbal medicine to treat a variety of diseases including nausea and vomiting, constipation, indigestion (dyspepsia), pain, and cold induced syndromes. More recently, it was reported that ginger also possesses anti-cancer, anti-clotting, anti-inflammatory, and anti-oxidative characteristics, since it can scavenge superoxide anion and hydroxyl radicals (2).
Ginger is known to contain a number of potentially bioactive substances, mainly gingerols and their related dehydration products, the shogaols, as well as volatile oils including sesquiterpenes, such as beta-bisabolene and (-)-zingiberene, and monoterpenes, mainly geranial and neral (9). In addition, phytochemical reports have shown that the main constituents of ginger are gingerol, shogaol, zingerone and paradol. It was reported that 6-gingerol and 6-shogaol are the major gingerol and shogaol present in the rhizome (1).
Ginger has been shown to possess anti-diabetic activity in a variety of studies. Akhani et al. (2004) reported that ginger pretreatment inhibited the induced hyperglycemia and hypoinsulinemia (10). Other investigators have showed the hypolipidemic effect of ginger (11). Other studies suggested that the response to ginger components depends on it''s potency in protection and treatment of metabolic disorders (6).
how to raise blood sugar level from 60 to 300 slots for fun 🔴how to how to raise blood sugar level from 60 to 300 slots for fun for Therefore, the present study was planned to evaluate the effects of ginger powder supplementation on serum levels of fasting blood sugar (FBS), Hemoglobin A1c (HbA1c), apolipoprotein B (apo B), apolipoprotein A-I (apo A-I), Apo B/Apo A-I, and malondialdehyde (MDA) in type 2 diabetic patients.
Materials and methods
The present study was a randomized, double blind, placebo controlled clinical trial performed on type 2 diabetic patients. The population of the study included all adult patients, aged 20-60 years old, who were referred to the Iran diabetes association in Tehran. The under study patients were diagnosed with non-insulin dependent diabetes mellitus (NIDDM) by an endocrinologist on the basis of the results of the blood tests and met the criteria of the study. These criteria included: disease duration at least 2 years, HbA1c level of 6-8%, taking no antioxidant supplements such as selenium, zinc and beta-carotene for at least 3 months prior to the study, no smoking and drinking. Exclusion criteria of the study were insulin therapy at baseline or during the study, changes in the type or dose of medication, changes in diet or daily physical activity, any acute illnesses or some chronic diseases including kidney, liver, cardiovascular, and gastrointestinal diseases, smoking, pregnancy and lactation, consumption of ginger or other botanical supplements, ginger hypersensitivity, and consumption of less than 80% of supplements during the study period.
Sample size was determined based on data from previous study (14) by considering type I error level α=0.05 with test power of 80%. To insure that the sample size, used in the study, could obtain the desired outcome for all relevant variables, the highest number of the calculated samples was considered. The sample size was computed as 20 per group. Regarding a possible loss to follow-up, a safety margin of 25% was determined, and therefore 25 patients were allocated in each group.
After attending the orientation session and fulfilling written informed consent paper, the participants were enrolled, and 50 eligible patients of either for 1 last update 2020/06/03 sex included in the study. After attending the orientation session and fulfilling written informed consent paper, the participants were enrolled, and 50 eligible patients of either sex included in the study.
Patients were divided randomly into two groups (experiment and control, 25 subjects in each) using computer''s recommendation. At the beginning of the study, information on socio-economic status of participants was collected by means of a questionnaire completed through an interview. The report of daily dietary intake was collected by a 24-hour diet recall questionnaire once at the beginning and at the end of the study. The data was then analyzed by Nutritionist IV software. The reports of the level of physical activity, at the beginning and the end of the study, were obtained through interview with individuals using the International Physical Activity Questionnaire (IPAQ). The patients were instructed to maintain their diet and physical activity during the intervention.
Anthropometric parameters including height and weight were measured at the beginning and the end of the intervention to calculate body mass index (BMI) as the formula (weight (Kg)/height squared (m2)). Body weight was measured without shoes and light clothing by using a seca scale with the precision of 0.5 Kg. Heights were also measured using a stadiometer without shoes with precision of 0.5 cm. During the 12-week intervention practice, the patients were called to resolve possible problems and ensure that the participants had consumed the drugs and supplements.
Blood samples (10 the 1 last update 2020/06/03 mL) were taken in a 10-12 hours fasting state at the beginning and after 12 weeks of intervention. The serum was obtained by high speed centrifugation and was frozen immediately at −80 °C until assay. Blood samples (10 mL) were taken in a 10-12 hours fasting state at the beginning and after 12 weeks of intervention. The serum was obtained by high speed centrifugation and was frozen immediately at −80 °C until assay.
The concentration of FBS was measured by enzymatic method using eliteh kit (via Hitachi machine) from French company of Feppim 717. Measurement of serum HbA1c level was performed by turbidometric inhibition immunoassay method using Roche kit from Germany. Apo B and apo A-I were also assayed by turbidometric immunoassay method using Roche kits (via Cobas machine) from Germany. Serum level of MDA was calculated by spectrophotometry method (Satoh 1978) (16) according to the instruction.
Fresh rhizomes of Zingiber officinale were purchased from local market and were ground as a fine particle after drying. The powder was delivered to a pharmaceutical lab (Tehran university of medical sciences, Iran) to prepare capsules containing 1 gram ginger in each (17). Lactose was also used to make placebo (18). The capsules were placed in the identical bottles by a third person not directly involved in this study. This person labeled the bottles with 2 cods which retained unknown for researchers and patients until the end of intervention. To evaluate the compliance of patients, bottles containing unconsumed ginger (or placebo) capsules were given monthly, and if was >20% of total delivered supplements the patient was excluded from the intervention.
The data were for 1 last update 2020/06/03 analyzed by SPSS software (version 16) and the results were expressed as mean ± standard deviation (Mean ± SD). The normality of the distribution of variables was determined by the Kolmogorov-Smirnov test. The differences in the levels of blood biochemical variables were compared, before and after the intervention, in each group. For variables with normal distribution, a paired t-test and for variables other than those, a wilcoxon test was used. To compare quantitative variables between the two groups, independent t-test and Mann-withney test were used for normal and non normal distribution variables, respectively. Differences with p-value <0.05 were considered to be statistically significant. The data were analyzed by SPSS software (version 16) and the results were expressed as mean ± standard deviation (Mean ± SD). The normality of the distribution of variables was determined by the Kolmogorov-Smirnov test. The differences in the levels of blood biochemical variables were compared, before and after the intervention, in each group. For variables with normal distribution, a paired t-test and for variables other than those, a wilcoxon test was used. To compare quantitative variables between the two groups, independent t-test and Mann-withney test were used for normal and non normal distribution variables, respectively. Differences with p-value <0.05 were considered to be statistically significant.
The protocol of study was in compliance with the Helsinki Convention of 1975 (revised in 2008) and informed consent form was obtained from each patient. The study was approved by the Ethics Committee of Public the 1 last update 2020/06/03 Health School of Tehran University of Medical Sciences (No. 2402), and registered in Iranian center of clinical trial registration with the ID number of IRCT 201109082709N19.The protocol of study was in compliance with the Helsinki Convention of 1975 (revised in 2008) and informed consent form was obtained from each patient. The study was approved by the Ethics Committee of Public Health School of Tehran University of Medical Sciences (No. 2402), and registered in Iranian center of clinical trial registration with the ID number of IRCT 201109082709N19.
Of 50 patients initially recruited, 41 persons (22 in the ginger group and 19 in the control group) completed the study, and 9 persons were excluded because of migration, change in type and dose of medication, and refusing to continue. There were 5 males and 17 females in the ginger group with an average age of 45.20 ± 7.64 years old and 9 males and 10 females with an average age of 47.10 ± 8.31 years in the control group.
There were no significant differences between the intervention and control groups regarding the distribution of sex, age, weight, waist circumference, body mass index (BMI), disease duration, type of consumed oral hypoglycemic drugs, daily dietary intake and the level of physical activity, at the beginning and the end of the study (p>0.05).
how to raise blood sugar level from 60 to 300 slots for fun 👍how to how to raise blood sugar level from 60 to 300 slots for fun for The table showed that there were no statistically significant differences in the baseline levels of FBS, HbA1c, Apo B, Apo A-I and Apo B/Apo A-I between the ginger and placebo groups (p>0.05), while the level of MDA was statistically different (p = 0.014).
Ginger supplementation significantly reduced the levels of FBS (p=0.000), HbA1c (p=0.000), Apo B (p=0.000), Apo B/Apo A-I (p=0.000) and MDA (p=0.001), as well as increased the level of Apo A-I (p=0.000) in the ginger group in comparison to the baseline. While the levels of FBS (p=0.048), Apo B (p=0.000), Apo B/Apo A-I (p=0.000) and MDA (p=0.004) increased, and Apo A-I (p=0.008) reduced in placebo group during the study. However, the statistical analysis indicated that the observed changes in control group may be the result of time effect, placebo empathic effect or other unknown factors, and it''s major component, gingerol, by inhibition of key enzymes relevant to type 2 diabetes, α-glucosidase and α-amylase, are known to improve diabetes (29). Li Y. et al. (2012) found that polar portion of ginger extract containing mainly gingerols, particularly (S)-- and (S)-- gingerol, promoted glucose uptake significantly in cultured rat skeletal muscle cells. This action of gingerols was attributed to facilitation of insulin-independent glucose uptake by increasing translocation of glucose transporter GLUT4 to the muscle cell plasma membrane surface, together with small increases in total GLUT4 protein expression (1). Another mechanism for reducing blood glucose by ginger hydroalcoholic extract, is the inhibition of hepatic phosphorylase enzyme, hereby it prevents the breakdown of hepatic glycogen storages, also, can increases the activity of enzymes improving glycogen synthesis. The other possible effect is suppression the activity of hepatic "" enzyme, that causes degradation of glucose 6-phosphate to glucose, and consequently increases blood glucose level (30). In-vitro studies suggested that ethyl acetate extract of ginger have inhibitory effect on the two key enzymes of glucose metabolism (α-amylase and α-glucosidase); the function of ginger against these two enzymes was found to be correlated with phenolic content of gingerol and shogaol at these extracts. Ginger has been shown to modulate insulin release. Ginger promotes glucose clearances in insulin responsive peripheral tissues, which is crucial in maintaining blood glucose homeostasis (29). As well as, it is reported that 6-gingerol increases the glucose uptake at insulin responsive adipocytes (31). Thus, at treated cells with gingerol, insulin responsive glucose uptake has increased and improved diabetes (30). Several studies stated that ginger have permanent effects of reducing lipids, and accordingly, increases insulin sensitivity. Owing to some studies showed that increasing the level of plasma free fatty acids (FFAs) lead to insulin resistance, ginger indicate anti-insulin resistance effects by reducing the level of plasma FFAs (32). Elshater A.A.E. et al. (2009) indicated that daily oral administration of ginger extract (4 mg/Kg) to STZ-diabetic rats resulted in reducing the plasma level of glucose, total cholesterol, LDL-C, and increasing HDL-C, comparing to control rats (2). The hypocholesterolemic effects of ginger may be due to the inhibition of cellular cholesterol synthesis, since, ((E)-8 beta, 17-epoxyllabed-12-ene-15, 16 dial) compound was isolated from ginger and interfered with cholesterol biosynthesis in liver homogenate in hypercholesterolemic mice causing it''s antioxidant activity, because ginger have many phenolic compounds, which have inhibitory effects on lipid peroxidation and preserve the antioxidant compounds (33). The basic concentration of the serum glucose of the rabbits in that study was lower than that of our study patients, the rabbits were not diabetic; as well as, the comparison between that study findings with our finding was impossible, because it may be different the glucose metabolism in humans and rabbits body.
In conclusion, the present study showed that ginger supplementation significantly reduced the levels of FBS, HbA1c, Apo B, Apo B/Apo A-I and MDA, and increased the level of Apo A-I in type 2 diabetic patients. Regarding negligible side effects of ginger, it may be a good remedy for diabetic patients to diminish the risk of some secondary chronic complications.
The present study was the first human research investigating the effects of ginger on glycemic status and stress oxidative in type 2 diabetic patients whose information regarding potential confounding variables, including dietary intake and physical activity level were available. However, this study had limitations, as well. First, several patients participating in the intervention, were excluded from the study. Moreover, frequent inclusion criteria, especially having no metabolic diseases and taking no antioxidant supplements, led to further reduction in the number of patients eligible for the study and hampered the disease finding process with many difficulties.
how to raise blood sugar level from 60 to 300 slots for fun 👍how to how to raise blood sugar level from 60 to 300 slots for fun for Finally, it is suggested to perform similar studies with higher number of patients and longer study period for a better observation of the effects of ginger in improving diabetic patient status.
This study has been supported by a grant from Research Vice-Chancellor of Tehran University of Medical Sciences (Tehran, Iran). The authors thank Iran association of diabetes for helping in recruiting patients. We are also grateful to all participants of the study that this project was made possible only with the cooperation and support of them.